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MDM2 Antibody

CAT: 0223-79-653Size: 0.1 mgDry Ice: NoHazardous: No
CAT#:0223-79-653Size:0.1 mg
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Background
MDM2, a ubiquitin ligase for p53, plays a central role in regulation of the stability of p53 . Akt-mediated phosphorylation of MDM2 at Ser166 and Ser186 increases its interaction with p300, allowing MDM2-mediated ubiquitination and degradation of p53 . Phosphorylation of MDM2 also blocks its binding to p19ARF, increasing the degradation of p53 .
NCBI Gene ID
4193
Swiss Prot
Q00987
Accession Number
NP_002383.2
Host
Rabbit
Reactivity
Human
Immunogen
MDM2 antibody was raised against a peptide sequence around aa.18~22 (Q-I-P-A-S) derived from Human MDM2. .
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
90 kDa
Specificity
This antibody detects endogenous levels of total MDM2 protein.
Applications Notes
Western Blot: 1:500~1:1000
Symbol
MDM2
NCBI Official Name
MDM2 oncogene, E3 ubiquitin protein ligase
NCBI Organism
Homo sapiens
Background Reference 01
Haupt, Y. et al. (1997) Nature 387, 296-299. Mayo, L. D. and Donner, D. B. (2001) Proc. Natl. Acad. Sci. USA 98, 11598-11603. Zhou, B. P. et al. (2001) Nat. Cell Biol. 3, 973-981. Grossman, S. R. et al. (1998) Mol. Cell 2, 405-415.
Other Product Names
HDMX, hdm2, ACTFS, CCN5, CT58, CTGFL, UNQ228/PRO261, HDMX
Tested Applications
WB
Protein ID
89993689
Physical Properties
Liquid

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