KRAS degrader-1

KRAS degrader-1

• CAS Number: 2795275-59-9
• UNSPSC Description: KRAS degrader-1 (compound 1) is a potent KRAS degrader. KRAS degrader-1 target specific proteins for degradation through the autophagy-lysosomal degradation pathway[1].
• Target Antigen: PROTACs; Ras
• Type: Reference compound
• Related Pathways: GPCR/G Protein;MAPK/ERK Pathway;PROTAC
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/kras-degrader-1.html
• Solubility: 10 mM in DMSO
• Smiles: BrC(C=C(C=C1Br)/C=C2C3=CC(I)=CC=C3NC/2=O)=C1OCCOCCOCCOCCCN(CCC4)[C@@H]4COC5=NC(N6C[C@@H](N(CC6)C(C(F)=C)=O)CC#N)=C7C(CN(C8=CC=CC9=C8C(Cl)=CC=C9)CC7)=N5
• Molecular Weight: 1283.25
• References & Citations: [1]Nan JI, et al. Methods and compounds for targeted autophagy. WO2022140246A1.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported