And1 degrader 1

And1 degrader 1

• CAS Number: 3029132-46-2
• UNSPSC Description: And1 degrader 1 (Compound A15) is a degrader of the acidic nucleoplasmic DNA-binding protein 1 (And1), which can significantly induce the degradation of And1 in NSCLC cells. And1 degrader 1 (5 μM) combined with Olaparib (HY-10162) (1 μM) effectively inhibits the proliferation of A549 and H460 cells. And1 degrader 1 can be used in cancer research[1].
• Target Antigen: DNA/RNA Synthesis
• Type: Reference compound
• Related Pathways: Cell Cycle/DNA Damage
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/and1-degrader-1.html
• Smiles: OC1=CC=C(/C=C/C2=CC=C(Cl)C(Cl)=C2)C=C1CNC3=CC=C(N4CCN(C)CC4)C=C3
• Molecular Weight: 468.42
• References & Citations: [1]Chen L, et al. Design, synthesis, and evaluation of novel stilbene derivatives that degrade acidic nucleoplasmic DNA-binding protein 1 (And1) and synergize with PARP1 inhibitor in NSCLC cells. J Enzyme Inhib Med Chem. 2024 Dec;39(1):2383886.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported