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PU-48

CAT: 0804-HY-155642-05Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-155642-05Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PU-48 is a potent urea transporters A (UT-A) inhibitor (IC50=0.32 μM) . PU-48 has a good diuretic effect in mouse models, and shows little or no cytotoxicity. PU-48 has the potential to be developed as a diuretic[1].
CAS Number
335394-78-0
UNSPSC
12352005
Target
Urea Transporter
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/pu-48.html
Purity
99.64
Solubility
DMSO : 6.67 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=C(N)C2=C(N=C3C=CC(OC)=CC3=C2)S1)OC
Molecular Formula
C14H12N2O3S
Molecular Weight
288.32
References & Citations
[1]Ren H, et al. Thienoquinolins exert diuresis by strongly inhibiting UT-A urea transporters. Am J Physiol Renal Physiol. 2014 Dec 15;307 (12) :F1363-72.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Methyl 3-amino-6-methoxythieno[2,3-b]quinoline-2-carboxylate
CAS Number335394-78-0
PubChem CID865472
IUPAC Namemethyl 3-amino-6-methoxythieno[2,3-b]quinoline-2-carboxylate
Molecular FormulaC14H12N2O3S
Molecular Weight288.32
XLogP3.6
Topological Polar Surface Area103
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Heavy Atom Count20
Formal Charge0
Complexity381
SMILES
COC1=CC2=CC3=C(N=C2C=C1)SC(=C3N)C(=O)OC
InChI
InChI=1S/C14H12N2O3S/c1-18-8-3-4-10-7(5-8)6-9-11(15)12(14(17)19-2)20-13(9)16-10/h3-6H,15H2,1-2H3
InChIKey
XRJKHUHLPVGTCL-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Methyl 3-amino-6-methoxythieno[2,3-b]quinoline-2-carboxylate
CAS: 335394-78-0
CID: 865472
Formula: C14H12N2O3S
MW: 288.32
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight288.32
XLogP33.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count6
Rotatable Bond Count3
Exact Mass288.05686342
Monoisotopic Mass288.05686342
Topological Polar Surface Area103 Ų
Heavy Atom Count20
Formal Charge0
Complexity381
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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