PI3K-IN-48

CAT: 0804-HY-156080Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-156080Size:1 Each
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Description
PI3K-IN-48 is a PI3K inhibitor with IC50 value of 1.55 ± 0.18 μM for A549 cells. PI3K-IN-48 can induce G0/G1 phase arrest, cell apoptosis, and down-regulate expression of p-PI3K and p-Akt. PI3K-IN-48 can be used for human lung cancers diseases research[1].
UNSPSC
12352005
Target
Akt; PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pi3k-in-48.html
Solubility
10 mM in DMSO
Smiles
COC1=CC(OC)=C(C=C1C2=NC3=CC(OC)=C(C=C3N2)C#CC4=C(C=CC=C4)F)OC
Molecular Formula
C25H21FN2O4
Molecular Weight
432.44
References & Citations
[1]Wu W, et al. Design, synthesis and antitumor effects of novel benzimidazole derivatives as PI3K inhibitors. Bioorg Med Chem Lett. 2023 Sep 7;95:129469.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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