HPK1-IN-48

• UNSPSC Description:

  HPK1-IN-48 (compound 14g) is a potent Hematopoietic Progenitor Kinase 1 (HPK1) inhibitor with a IC50 of 0.15 nM. HPK1-IN-48 significantly suppresses the phosphorylation of SLP76 with a IC50 of 27.92 nM[1].

• Target Antigen:

  MAP4K

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/hpk1-in-48.html

• Smiles:

  COC1=C(C=CC(N2CC(N(C(C2)C)C)C)=C1)NC3=C(C=NC(NC4=CC=C(C=C4)C(NCC5=CC=CC=C5)=O)=N3)C(N)=O

• Molecular Weight:

  594.71

• References & Citations:

  [1]Fu S, et al. Design, synthesis, and biological evaluation of 2,4-diaminopyrimidine derivatives as potent Hematopoietic Progenitor Kinase 1 (HPK1) inhibitors. Bioorg Chem. 2024 Jul;148:107454.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported