PU-48

CAT: 0804-HY-155642-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-155642-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

PU-48 is a potent urea transporters A (UT-A) inhibitor (IC50=0.32 μM) . PU-48 has a good diuretic effect in mouse models, and shows little or no cytotoxicity. PU-48 has the potential to be developed as a diuretic[1].

CAS Number

335394-78-0

UNSPSC

12352005

Target

Urea Transporter

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/pu-48.html

Purity

99.64

Solubility

DMSO : 6.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1=C(N)C2=C(N=C3C=CC(OC)=CC3=C2)S1)OC

Molecular Formula

C14H12N2O3S

Molecular Weight

288.32

References & Citations

[1]Ren H, et al. Thienoquinolins exert diuresis by strongly inhibiting UT-A urea transporters. Am J Physiol Renal Physiol. 2014 Dec 15;307 (12) :F1363-72.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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