PU-48

• Description :

  PU-48 is a potent urea transporters A (UT-A) inhibitor (IC50=0.32 μM) . PU-48 has a good diuretic effect in mouse models, and shows little or no cytotoxicity. PU-48 has the potential to be developed as a diuretic[1].

• UNSPSC :

  12352005

• Target :

  Urea Transporter

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/pu-48.html

• Purity :

  99.64

• Solubility :

  DMSO : 6.67 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  O=C(C1=C(N)C2=C(N=C3C=CC(OC)=CC3=C2)S1)OC

• Molecular Formula :

  C14H12N2O3S

• Molecular Weight :

  288.32

• References & Citations :

  [1]Ren H, et al. Thienoquinolins exert diuresis by strongly inhibiting UT-A urea transporters. Am J Physiol Renal Physiol. 2014 Dec 15;307 (12) :F1363-72.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [335394-78-0]