PU-48

• UNSPSC Description:

  PU-48 is a potent urea transporters A (UT-A) inhibitor (IC50=0.32 μM). PU-48 has a good diuretic effect in mouse models, and shows little or no cytotoxicity. PU-48 has the potential to be developed as a diuretic[1].

• Target Antigen:

  Urea Transporter

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/pu-48.html

• Solubility:

  DMSO : 6.67 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  O=C(C1=C(N)C2=C(N=C3C=CC(OC)=CC3=C2)S1)OC

• Molecular Weight:

  288.32

• References & Citations:

  [1]Ren H, et al. Thienoquinolins exert diuresis by strongly inhibiting UT-A urea transporters. Am J Physiol Renal Physiol. 2014 Dec 15;307(12):F1363-72.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  335394-78-0