JG-48

• Description:

  JG-48 is a Hsp70 inhibitor that can reduce tau levels in models of tauopathy[1].

• UNSPSC:

  12352005

• Target:

  HSP

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/jg-48.html

• Smiles:

  O=C1N (CC) /C (S/C1=C2SC3=CC (C (F) (F) F) =CC=C3N/2C) =C/C4=NC=CC=C4

• Molecular Formula:

  C20H16F3N3OS2

• Molecular Weight:

  435.49

• References & Citations:

  [1]Young ZT, et al. Stabilizing the Hsp70-Tau Complex Promotes Turnover in Models of Tauopathy. Cell Chem Biol. 2016 Aug 18;23 (8) :992-1001.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1627122-26-2