STAT3-IN-48

CAT: 0804-HY-136658-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-136658-01Size:5 mg
Selected
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
STAT3-IN-48 is a Sorafenib analogue and potently inhibits the phosphorylation of STAT3. STAT3-IN-48 induces cell apoptosis through SHP-1 dependent STAT3 inactivation. STAT3-IN-48 does not inhibit kinase activity and has anticancer effects[1].
CAS Number
[1313019-65-6]
UNSPSC
12352005
Hazard Statement
H319, H413
Target
Apoptosis; STAT
Type
Reference compound
Related Pathways
Apoptosis; JAK/STAT Signaling; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/stat3-in-7.html
Purity
98.02
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(OC2=CC=C(C#N)C=C2)C=C1)NC3=CC=C(Cl)C(C(F)(F)F)=C3
Molecular Formula
C21H13ClF3N3O2
Molecular Weight
431.80
Precautions
H319, H413
References & Citations
[1]Chun-Yu Liu, et al. Novel sorafenib analogues induce apoptosis through SHP-1 dependent STAT3 inactivation in human breast cancer cells. Breast Cancer Res. 2013;15 (4) :R63.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
STAT3

Alternative Products

Popular Products