PU-WS13

• Description :

  PU-WS13 is a selective Grp94 inhibitor, with an EC50 of 0.22 μM.

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  HSP

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/PU-WS13.html

• Concentration :

  10mM

• Purity :

  99.88

• Solubility :

  DMSO : ≥ 40 mg/mL

• Smiles :

  CC(NCCCN1C(SC2=CC(Cl)=CC(Cl)=C2)=NC3=C(N)N=CN=C13)C

• Molecular Formula :

  C17H20Cl2N6S

• Molecular Weight :

  411.35

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Patel PD, et al. Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2. Nat Chem Biol. 2013 Nov;9 (11) :677-684.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  HSP90

• CAS Number :

  [1454619-14-7]