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Z-DEVD-AFC

CAT: 0804-HY-P1986-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P1986-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Z-DEVD-AFC is a cell-permeant substrate for caspase-3, which causes a shift in fluorescence uponcleavage of the AFC fluorophore. Z-DEVD-AFC can be used to detect caspase-3-like enzymes activity[1].
CAS Number
1135416-11-3
UNSPSC
12171500
Target
Caspase
Type
Dye Reagents
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/z-devd-afc.html
Purity
98.08
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
FC(F)(C(C1=CC=C(NC([C@H](CC(O)=O)NC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC([C@H](CC(O)=O)NC(OCC2=CC=CC=C2)=O)=O)=O)=O)=O)C=C1O3)=CC3=O)F
Molecular Formula
C36H38F3N5O14
Molecular Weight
821.71
References & Citations
[1]Santiago AR, et al. High glucose induces caspase-independent cell death in retinal neural cells. Neurobiol Dis. 2007;25 (3) :464-472.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Dye Reagents
Clinical Information
No Development Reported

Chemical Information

Z-Devd-afc
CAS Number1135416-11-3
PubChem CID25108569
IUPAC Name(4S)-5-[[(2S)-1-[[(2S)-3-carboxy-1-oxo-1-[[2-oxo-4-(trifluoromethyl)chromen-7-yl]amino]propan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-[[(2S)-3-carboxy-2-(phenylmethoxycarbonylamino)propanoyl]amino]-5-oxopentanoic acid
Molecular FormulaC36H38F3N5O14
Molecular Weight821.7
XLogP1.1
Topological Polar Surface Area293
Hydrogen Bond Donor Count8
Hydrogen Bond Acceptor Count17
Rotatable Bond Count20
Heavy Atom Count58
Formal Charge0
Complexity1600
SMILES
CC(C)[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)NC1=CC2=C(C=C1)C(=CC(=O)O2)C(F)(F)F)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)OCC3=CC=CC=C3
InChI
InChI=1S/C36H38F3N5O14/c1-17(2)30(34(55)42-23(14-27(47)48)32(53)40-19-8-9-20-21(36(37,38)39)13-29(51)58-25(20)12-19)44-31(52)22(10-11-26(45)46)41-33(54)24(15-28(49)50)43-35(56)57-16-18-6-4-3-5-7-18/h3-9,12-13,17,22-24,30H,10-11,14-16H2,1-2H3,(H,40,53)(H,41,54)(H,42,55)(H,43,56)(H,44,52)(H,45,46)(H,47,48)(H,49,50)/t22-,23-,24-,30-/m0/s1
InChIKey
JEPURZRNABGOCW-CQUCHYGKSA-N
Chemical Structure
2D Structure
2D structure of Z-Devd-afc
CAS: 1135416-11-3
CID: 25108569
Formula: C36H38F3N5O14
MW: 821.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight821.7
XLogP31.1
Hydrogen Bond Donor Count8
Hydrogen Bond Acceptor Count17
Rotatable Bond Count20
Exact Mass821.23673539
Monoisotopic Mass821.23673539
Topological Polar Surface Area293 Ų
Heavy Atom Count58
Formal Charge0
Complexity1600
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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