Z-VDVAD-AFC

Z-VDVAD-AFC

• CAS Number: 219138-08-6
• UNSPSC Description: Z-VDVAD-AFC is a fluorogenic substrate. Z-VDVAD-AFC is used to measure the activity of cysteine protease 3 (Caspase-3). Z-VDVAD-AFC undergoes hydrolysis to release 7-amino-4-trifluoromethylcoumarin (AFC). AFC is fluorescent under ultraviolet light and can emit fluorescent signals[1].
• Target Antigen: Fluorescent Dye
• Type: Peptides
• Related Pathways: Others
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/z-vdvad-afc.html
• Solubility: 10 mM in DMSO
• Smiles: FC(F)(C(C1=CC=C(NC([C@H](CC(O)=O)NC([C@H](C)NC([C@H](C(C)C)NC([C@H](CC(O)=O)NC([C@H](C(C)C)NC(OCC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)C=C1O3)=CC3=O)F
• Molecular Weight: 862.80
• References & Citations: [1]Pallepati P, et, al. Mild thermotolerance induced at 40°C protects HeLa cells against activation of death receptor-mediated apoptosis by hydrogen peroxide. Free Radic Biol Med. 2011 Mar 15;50(6):667-79.|[2]Pallepati P, et, al. Mild thermotolerance induced at 40°C protects HeLa cells against activation of death receptor-mediated apoptosis by hydrogen peroxide. Free Radic Biol Med. 2011 Mar 15;50(6):667-79.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported