Z-DEVD-AFC

• UNSPSC Description:

  Z-DEVD-AFC is a cell-permeant substrate for caspase-3, which causes a shift in fluorescence uponcleavage of the AFC fluorophore. Z-DEVD-AFC can be used to detect caspase-3-like enzymes activity[1].

• Target Antigen:

  Caspase

• Type:

  Dye Reagents

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/z-devd-afc.html

• Purity:

  98.95

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  FC(F)(C(C1=CC=C(NC([C@H](CC(O)=O)NC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC([C@H](CC(O)=O)NC(OCC2=CC=CC=C2)=O)=O)=O)=O)=O)C=C1O3)=CC3=O)F

• Molecular Weight:

  821.71

• References & Citations:

  [1]Santiago AR, et al. High glucose induces caspase-independent cell death in retinal neural cells. Neurobiol Dis. 2007;25(3):464-472.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  1135416-11-3