GSPT1 degrader-3
CAT:
804-HY-157426
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
GSPT1 degrader-3
- UNSPSC Description: GSPT1 degrader-3 (Pro-2) is a CRBN-based PROTAC degrader for BRD, with a DC50 of 21.1 nM (4h)[1].
- Target Antigen: Epigenetic Reader Domain; PROTACs
- Type: Reference compound
- Related Pathways: Epigenetics;PROTAC
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/gspt1-degrader-3.html
- Solubility: 10 mM in DMSO
- Smiles: O=C(NC1=O)CCC1N2CC3=CC(C4CCN(CCNC(C[C@@H](C5=NN=C(C)N56)N=C(C7=CC=C(Cl)C=C7)C8=C6SC(C)=C8C)=O)CC4)=CC=C3C2=O
- Molecular Weight: 753.31
- References & Citations: [1]Christine M Arndt, et al. One-Pot Synthesis of Cereblon Proteolysis Targeting Chimeras via Photoinduced C(sp2)-C(sp3) Cross Coupling and Amide Formation for Proteolysis Targeting Chimera Library Synthesis. J Med Chem. 2023 Dec 28;66(24):16939-16952.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported