GSPT1 degrader-3

• UNSPSC Description:

  GSPT1 degrader-3 (Pro-2) is a CRBN-based PROTAC degrader for BRD, with a DC50 of 21.1 nM (4h)[1].

• Target Antigen:

  Epigenetic Reader Domain; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/gspt1-degrader-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NC1=O)CCC1N2CC3=CC(C4CCN(CCNC(C[C@@H](C5=NN=C(C)N56)N=C(C7=CC=C(Cl)C=C7)C8=C6SC(C)=C8C)=O)CC4)=CC=C3C2=O

• Molecular Weight:

  753.31

• References & Citations:

  [1]Christine M Arndt, et al. One-Pot Synthesis of Cereblon Proteolysis Targeting Chimeras via Photoinduced C(sp2)-C(sp3) Cross Coupling and Amide Formation for Proteolysis Targeting Chimera Library Synthesis. J Med Chem. 2023 Dec 28;66(24):16939-16952.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported