VAV1 degrader-3
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804-HY-168625
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
VAV1 degrader-3
- CAS Number: 3050683-38-7
- UNSPSC Description: VAV1 degrader-3 (Example 185) is an orally active VAV1 molecular glue degrader (DC50: 7 nM). VAV1 degrader-3 reduces immune cell activation, immune cell proliferation and the production of various cytokines. VAV1 degrader-3 can be used for research of inflammatory or autoimmune disorder. VAV1 degrader-3 inhibits disease progression in experimntal autoimmune encephalomyelitis (EAE) mouse model, Collagen-induced arthritis (CIA) mouse model, etc.[1].
- Target Antigen: Molecular Glues
- Type: Reference compound
- Related Pathways: PROTAC
- Applications: COVID-19-immunoregulation
- Field of Research: Inflammation/Immunology
- Assay Protocol: https://www.medchemexpress.com/vav1-degrader-3.html
- Smiles: ClC1=C(C2CCC(NC2=O)=O)C=CC=C1C3=CC=C(N4C(C=CC=C4)=O)C=C3
- Molecular Weight: 392.83
- References & Citations: [1]Laura Ann Mcallister, et al. Targeted degradation of vav1. Patent. WO2024151547A1.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported