24-Hydroxycholesterol

• Description:

  24-Hydroxycholesterol is a natural sterol, which serves as a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factors LXR.

• UNSPSC:

  12352211

• Target:

  IGluR; LXR

• Type:

  Natural Products

• Related Pathways:

  Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Vitamin D Related/Nuclear Receptor

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/24-Hydroxycholesterol.html

• Purity:

  99.90

• Solubility:

  DMSO : 3.67 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 60 mg/mL (ultrasonic)

• Smiles:

  CC (C) C (O) CC[C@@H] (C) [C@H]1CC[C@@]2 ([H]) [C@]3 ([H]) CC=C4C[C@@H] (O) CC[C@]4 (C) [C@@]3 ([H]) CC[C@]12C

• Molecular Formula:

  C27H46O2

• Molecular Weight:

  402.65

• References & Citations:

  [1]Soncini M, et al. 24-Hydroxycholesterol participates in pancreatic neuroendocrine tumor development. Proc Natl Acad Sci U S A. 2016 Oct 11;113 (41) :E6219-E6227. Epub 2016 Sep 26.|[2]Mast N, et al. Cholesterol-metabolizing enzyme cytochrome P450 46A1 as a pharmacologic target for Alzheimer's disease. Neuropharmacology. 2017 Sep 1;123:465-476.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  NMDA Receptor

• CAS Number:

  30271-38-6