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24-Hydroxycholesterol

CAT: 0804-HY-N2370-01Size: 2 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N2370-01Size:2 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
24-Hydroxycholesterol is a natural sterol, which serves as a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factors LXR.
CAS Number
[30271-38-6]
UNSPSC
12352211
Target
IGluR; LXR
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Vitamin D Related/Nuclear Receptor
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/24-Hydroxycholesterol.html
Purity
99.90
Solubility
DMSO : 3.67 mg/mL (ultrasonic; warming; heat to 60°C) |Ethanol : 60 mg/mL (ultrasonic)
Smiles
CC(C)C(O)CC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
Molecular Formula
C27H46O2
Molecular Weight
402.65
References & Citations
[1]Soncini M, et al. 24-Hydroxycholesterol participates in pancreatic neuroendocrine tumor development. Proc Natl Acad Sci U S A. 2016 Oct 11;113 (41) :E6219-E6227. Epub 2016 Sep 26.|[2]Mast N, et al. Cholesterol-metabolizing enzyme cytochrome P450 46A1 as a pharmacologic target for Alzheimer's disease. Neuropharmacology. 2017 Sep 1;123:465-476.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
NMDA Receptor

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