25-Hydroxycholesterol

• Description:

  25-Hydroxycholesterol (25-OHC) is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells.

• Product Name Alternative:

  25-OHC

• UNSPSC:

  12352211

• Hazard Statement:

  H302, H312, H315, H319, H332, H335, H373

• Target:

  Endogenous Metabolite

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/25-Hydroxycholesterol.html

• Purity:

  99.98

• Solubility:

  DMSO : 5 mg/mL (ultrasonic) |Ethanol : 14.29 mg/mL (ultrasonic)

• Smiles:

  CC(C)(O)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C

• Molecular Formula:

  C27H46O2

• Molecular Weight:

  402.65

• Precautions:

  H302, H312, H315, H319, H332, H335, H373

• References & Citations:

  [1]McDonald JG, et al. Editorial: 25-Hydroxycholesterol: a new life in immunology. J Leukoc Biol. 2010 Dec;88 (6) :1071-2.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Natural Products

• Clinical Information:

  No Development Reported

• Isoform:

  Human Endogenous Metabolite

• CAS Number:

  [2140-46-7]