25-Hydroxycholesterol

• Description :

  25-Hydroxycholesterol (25-OHC) is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells.

• Product Name Alternative :

  25-OHC

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H312, H315, H319, H332, H335, H373

• Target :

  Endogenous Metabolite

• Type :

  Natural Products

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/25-Hydroxycholesterol.html

• Purity :

  99.98

• Solubility :

  DMSO : 5 mg/mL (ultrasonic) |Ethanol : 14.29 mg/mL (ultrasonic)

• Smiles :

  CC(C)(O)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C

• Molecular Formula :

  C27H46O2

• Molecular Weight :

  402.65

• Precautions :

  H302, H312, H315, H319, H332, H335, H373

• References & Citations :

  [1]McDonald JG, et al. Editorial: 25-Hydroxycholesterol: a new life in immunology. J Leukoc Biol. 2010 Dec;88 (6) :1071-2.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  Human Endogenous Metabolite

• CAS Number :

  [2140-46-7]