24 (S)-Hydroxycholesterol

CAT: 0026-2411-1Size: 1 mgDry Ice: NoHazardous: No
CAT#:0026-2411-1Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
An important cholesterol metabolite (cholesterol 24-hydroxylase) found in the brain.  It is an endogenous agonist of the nuclear receptor LXR. It has been shown to induce cell death in neuroblastoma cells, possibly via a necroptosis pathway.  24(S)-Hydroxycholesterol has also been found to be a high affinity ligand for RORα and RORγ (Ki = 25 nM). 24(S)-Hydroxycholesterol levels are elevated in the cerebral spinal fluids of patients with neurogenerative diseases suggesting possible clinical applications. It was also able to reduce Aβ production and increase ER-resident immature amyloid precursor protein (APP) levels in human neuroblastoma SH-Sy5Y cells and CHO cells via inhibition of intracellular amyloid precursor protein trafficking.
Shipping Conditions
gel pack
Storage Conditions
-20 ̊C
Shelf Life
36 months

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