27-Hydroxycholesterol

CAT: 0804-HY-N2371-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-N2371-01Size:1 mg
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Description
27-Hydroxycholesterol (27-OHC) is a selective estrogen receptor modulator and an agonist of the liver X receptor.
CAS Number
[20380-11-4]
Product Name Alternative
27-OHC
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite; Estrogen Receptor/ERR; LXR
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/27-Hydroxycholesterol.html
Concentration
10mM
Purity
99.77
Solubility
DMSO : 1 mg/mL (ultrasonic) |Ethanol : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C[C@@H](CO)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
Molecular Formula
C27H46O2
Molecular Weight
402.65
Precautions
H302, H315, H319, H335
References & Citations
[1]DuSell CD, et al. 27-hydroxycholesterol is an endogenous selective estrogen receptor modulator. Mol Endocrinol. 2008 Jan;22 (1) :65-77.|[2]Raza S, et al. The cholesterol metabolite 27-hydroxycholesterol stimulates cell proliferation via ERβ in prostate cancer cells. Cancer Cell Int. 2017 May 11;17:52.|[3]Kimbung S, et al. Impact of 27-hydroxylase (CYP27A1) and 27-hydroxycholesterol in breast cancer. Endocr Relat Cancer. 2017 Jul;24 (7) :339-349.|[4]Fu X, et al. 27-hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells. J Biol Chem. 2001 Oct 19;276 (42) :38378-87.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite

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