24 (S) -Hydroxycholesterol

• Description :

  24 (S) -Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24 (S) -Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous LXR agonist known and is present in the brain and in the circulation at relatively high levels. 24 (S) -Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators[1][2][3].

• Product Name Alternative :

  24S-OHC; 24S-HC; Cerebrosterol

• UNSPSC :

  12352211

• Target :

  Endogenous Metabolite; iGluR; LXR

• Type :

  Natural Products

• Related Pathways :

  Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Vitamin D Related/Nuclear Receptor

• Applications :

  Metabolism-sugar/lipid metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/24_S_-Hydroxycholesterol.html

• Purity :

  99.75

• Solubility :

  DMSO : 12.5 mg/mL (ultrasonic) |Ethanol : 20 mg/mL (ultrasonic; warming)

• Smiles :

  C[C@H](CC[C@H](O)C(C)C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C

• Molecular Formula :

  C27H46O2

• Molecular Weight :

  402.65

• References & Citations :

  [1]Yuki Kimura, et al. Tocopherol suppresses 24 (S) -hydroxycholesterol-induced cell death via inhibition of CaMKII phosphorylation. Biochimie. 2018 Oct;153:203-209.|[2]M Shafaati, et al. Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo. J Intern Med. 2011 Oct;270 (4) :377-87.|[3]Steven M Paul, et al. The major brain cholesterol metabolite 24 (S) -hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors. J Neurosci. 2013 Oct 30;33 (44) :17290-300.|[4]Ishikawa M, et al. 24 (S) -Hydroxycholesterol protects the ex vivo rat retina from injury by elevated hydrostatic pressure. Sci Rep. 2016 Sep 22;6:33886.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  Human Endogenous Metabolite; NMDA Receptor

• CAS Number :

  [474-73-7]