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24 (S) -Hydroxycholesterol

CAT: 0804-HY-16940-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-16940-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
24 (S) -Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24 (S) -Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous LXR agonist known and is present in the brain and in the circulation at relatively high levels. 24 (S) -Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators[1][2][3].
CAS Number
474-73-7
Product Name Alternative
24S-OHC; 24S-HC; Cerebrosterol
UNSPSC
12352211
Target
Endogenous Metabolite; iGluR; LXR
Type
Natural Products
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Vitamin D Related/Nuclear Receptor
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/24_S_-Hydroxycholesterol.html
Purity
99.75
Solubility
DMSO : 12.5 mg/mL (ultrasonic) |Ethanol : 20 mg/mL (ultrasonic; warming)
Smiles
C[C@H](CC[C@H](O)C(C)C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
Molecular Formula
C27H46O2
Molecular Weight
402.65
References & Citations
[1]Yuki Kimura, et al. Tocopherol suppresses 24 (S) -hydroxycholesterol-induced cell death via inhibition of CaMKII phosphorylation. Biochimie. 2018 Oct;153:203-209.|[2]M Shafaati, et al. Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo. J Intern Med. 2011 Oct;270 (4) :377-87.|[3]Steven M Paul, et al. The major brain cholesterol metabolite 24 (S) -hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors. J Neurosci. 2013 Oct 30;33 (44) :17290-300.|[4]Ishikawa M, et al. 24 (S) -Hydroxycholesterol protects the ex vivo rat retina from injury by elevated hydrostatic pressure. Sci Rep. 2016 Sep 22;6:33886.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Human Endogenous Metabolite; NMDA Receptor

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