Products for Research Use Only
RegisterLogin

7β-Hydroxycholesterol

CAT: 0804-HY-113341-01Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-113341-01Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
7β-Hydroxycholesterol is an oxysterol that derived by the oxidation of cholesterol. 7β-hydroxycholesterol can induce cellular oxidative stress, apoptosis, and necrosis, resulting in cytotoxicity. 7β-hydroxycholesterol has antitumor activity[1][2][3][4].
CAS Number
566-27-8
Product Name Alternative
Methophenazine (diethanesulfonate), Methophenazine, U31928
UNSPSC
12352211
Target
Apoptosis; Interleukin Related; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/7β-hydroxycholesterol.html
Purity
99.98
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])[C@@H](O)C=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
Molecular Formula
C27H46O2
Molecular Weight
402.65
References & Citations
[1]Anne Vejux, et al. 7-Ketocholesterol and 7β-hydroxycholesterol: In vitro and animal models used to characterize their activities and to identify molecules preventing their toxicity. Biochem Pharmacol. 2020 Mar;173:113648.|[2]Lemaire S, et al. Different patterns of IL-1beta secretion, adhesion molecule expression and apoptosis induction in human endothelial cells treated with 7alpha-, 7beta-hydroxycholesterol, or 7-ketocholesterol. FEBS Lett. 1998 Dec 4;440 (3) :434-9.|[3]Lizard G, et al. Characterization and comparison of the mode of cell death, apoptosis versus necrosis, induced by 7beta-hydroxycholesterol and 7-ketocholesterol in the cells of the vascular wall. Arterioscler Thromb Vasc Biol. 1999 May;19 (5) :1190-200.|[4]Roussi S, et al. Different apoptotic mechanisms are involved in the antiproliferative effects of 7beta-hydroxysitosterol and 7beta-hydroxycholesterol in human colon cancer cells. Cell Death Differ. 2005 Feb;12 (2) :128-35.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-1

Related Products

CatalogName
HY-W4145817-Keto-27-hydroxycholesterol
HY-1339747-keto-25-Hydroxycholesterol
HY-N2370-0124-Hydroxycholesterol
HY-N2371-0127-Hydroxycholesterol
HY-124265-014β-Hydroxycholesterol
HY-113134-0125-Hydroxycholesterol
HY-W3539144α-Hydroxycholesterol
HY-N15915Ent-25-Hydroxycholesterol
HY-124265S4β-Hydroxycholesterol-d7
HY-113134R-0125-Hydroxycholesterol (Standard)

Alternative Products

CatalogName
B20179267β-Hydroxycholesterol
T19161-017α-Hydroxycholesterol
TRC-H917964-1MG7ß-Hydroxycholesterol-d7
H9179627α-Hydroxycholesterol-d7
GL3845-100mg7-beta-Hydroxycholesterol
GTR19183933-017 Beta-Hydroxycholesterol
ZNA55394-017±-hydroxycholesterol (D7)
T201105-017-Keto-27-hydroxycholesterol
H1030017-alpha-Hydroxycholesterol-d6
TRC-H772781-5MG7-beta-Hydroxycholesterol-D6

Popular Products