PF-05186462

CAT: 0804-HY-122001-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-122001-01Size:5 mg
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Description
PF-05186462 is a potent and selective inhibitor of human Nav1.7 voltage-dependent sodium channel, with an IC50 of 21 nM. PF-05186462 shows significant selectivity for Nav1.7 versus other sodium channels (Nav 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, and 1.8) . PF-05186462 can be used for the research of acute or chronic pain[1].
CAS Number
[1235406-03-7]
UNSPSC
12352005
Target
Sodium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pf-05186462.html
Purity
99.69
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=S(C1=CC(Cl)=C(OC2=CC=C(C(F)(F)F)C=C2C3=CC=NN=C3)C=C1F)(NC4=NN=CS4)=O
Molecular Formula
C19H10ClF4N5O3S2
Molecular Weight
531.89
References & Citations
[1]Jones HM, et, al. Clinical Micro-Dose Studies to Explore the Human Pharmacokinetics of Four Selective Inhibitors of Human Nav1.7 Voltage-Dependent Sodium Channels. Clin Pharmacokinet. 2016 Jul;55 (7) :875-887.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
Nav1.7

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