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PF-3644022

CAT: 0804-HY-107427-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107427-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF-3644022 is a potent, selective, orally active and ATP-competitive MAPKAPK2 (MK2) inhibitor with an IC50 of 5.2 nM and a Ki of 3 nM. PF-3644022 also inhibits MK3 and p38 regulated/activated kinase (PRAK) with IC50s of 53 nM and 5.0 nM, respectively. PF-3644022 potently inhibits TNFα production and has anti-inflammatory effect[1].
CAS Number
1276121-88-0
UNSPSC
12352005
Hazard Statement
H302, H319, H413
Target
MAPKAPK2 (MK2) ; p38 MAPK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Neuroscience-Neuromodulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pf-3644022.html
Concentration
10mM
Purity
99.65
Solubility
DMSO : 41.67 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C1C2=C(NC[C@@H](C)N1)C3=C(C=CC4=NC(C5=CN=C(C)C=C5)=CC=C34)S2
Molecular Formula
C21H18N4OS
Molecular Weight
374.46
Precautions
H302, H319, H413
References & Citations
[1]Mourey RJ, et al. A benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor alpha production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation. J Pharmacol Exp Ther. 2010 Jun;333 (3) :797-807
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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