PF-06422913

• Description:

  PF-06422913 is an orally active, potent and selective metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator[1].

• UNSPSC:

  12352005

• Target:

  MGluR

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Field of Research:

  Inflammation/Immunology

• Smiles:

  FC(F)(C1=C(C2=NN(C)C3=C2N=CC(OCC4=NC=CC=C4)=N3)C=NC=C1)F

• Molecular Formula:

  C18H13F3N6O

• Molecular Weight:

  386.33

• References & Citations:

  [1]Falgun Shah, et al. Mechanisms of Skin Toxicity Associated with Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators. Cell Chem Biol. 2017 Jul 20;24 (7) :858-869.e5.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  MGluR5

• CAS Number:

  [1539296-46-2]