PF-06658607

• Description:

  PF-06658607 is an alkynylated irreversible Brutons tyrosine kinase (BTK) inhibitor that covalently reacts with active site cysteines in the ATP-binding pocket. PF-06658607 can be used to detect "off "-targets for covalent kinase inhibitors in cancer cells. The alkyne moiety allows for azide-based detection probe via copper-catalyzed click chemistry[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H315, H319, H335

• Target:

  Btk

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Purity:

  99.69

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  C=CC(N1C[C@H](N2N=C(C3=CC=C(OC4=CC=CC(C#C)=C4)C=C3)C5=C(N)N=CN=C52)CCC1)=O

• Molecular Formula:

  C27H24N6O2

• Molecular Weight:

  464.52

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Lanning BR, et al. A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors. Nat Chem Biol. 2014 Sep;10 (9) :760-767.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [1621002-24-1]