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PF-4878691

CAT: 0804-HY-100176-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100176-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PF-4878691 (3M-852A) is an orally active TLR7 agonist. PF-4878691 has the innate immune response activity, antiviral efficacy against HCV, and can be used for the research of cancer[1][2].
CAS Number
532959-63-0
Product Name Alternative
3M-852A
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; HCV; Interleukin Related; TNF Receptor; Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation
Applications
COVID-19-anti-virus
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/PF-4878691.html
Purity
99.89
Solubility
DMSO : 19.23 mg/mL (ultrasonic)
Smiles
CS(=O)(NCCCCN1C(CC)=NC2=C1C3=CC=CC=C3N=C2N)=O
Molecular Formula
C17H23N5O2S
Molecular Weight
361.46
Precautions
H302, H315, H319, H335
References & Citations
[1]Fidock MD, et al. The innate immune response, clinical outcomes, and ex vivo HCV antiviral efficacy of a TLR7 agonist (PF-4878691) . Clin Pharmacol Ther. 2011 Jun;89 (6) :821-9.|[2]Horscroft NJ, et al. Antiviral applications of Toll-like receptor agonists. J Antimicrob Chemother. 2012 Apr;67 (4) :789-801.|[3]Birmachu W, et al. Transcriptional networks in plasmacytoid dendritic cells stimulated with synthetic TLR 7 agonists [J]. BMC immunology, 2007, 8: 1-19.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
IL-1; IL-2; IL-6; IL-8; TLR7

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