PF-04745637

• Description :

  PF-04745637 is a potent and selective TRPA1 antagonist with an IC50 of 17 nM for human TRPA1[1].

• UNSPSC :

  12352005

• Target :

  TRP Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/pf-04745637.html

• Purity :

  99.97

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(C1(C2=CC=C(Cl)C=C2)CCCC1)NCC(N3CCC(C(F)(F)F)(O)CC3)CC4=CC=CC=C4

• Molecular Formula :

  C27H32ClF3N2O2

• Molecular Weight :

  509.00

• References & Citations :

  [1]Laurie B. Schenkel, et al. The discovery of a potent series of carboxamide TRPA1 antagonists. J. Med. Chem. 2016, 59, 6, 2794-2809.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  TRPA1

• CAS Number :

  [1917294-46-2]