PF-06764427

CAT: 0804-HY-123852Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-123852Size:1 Each
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Description
PF-06764427 is a selective M1 muscarinic acetylcholine receptor positive allosteric modulator. PF-06764427 exhibits robust M1 agonist activity. PF-06764427 can be used in the research of Alzheimer's disease and schizophrenia[1][2].
CAS Number
[1842371-08-7]
UNSPSC
12352005
Target
MAChR
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
O=C(C1=CN(CC2=CC=C(C3=NN(C)C=C3)C=C2)C4=CC=CN=C41)N[C@@H]5[C@@H](O)COCC5
Molecular Formula
C24H25N5O3
Molecular Weight
431.49
References & Citations
[1]Davoren JE, et al. Design and optimization of selective azaindole amide M1 positive allosteric modulators. Bioorg Med Chem Lett. 2016 Jan 15;26 (2) :650-655. |[2]Moran SP, et al. M1-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition. Neuropsychopharmacology. 2018 Jul;43 (8) :1763-1771.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAChR1

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