STAT3-IN-11
CAT:
804-HY-149007-01
Size:
10 mM / 1 mL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
STAT3-IN-11
- CAS Number: 2503096-50-0
- UNSPSC Description: STAT3-IN-11 (7a) is a selective STAT3 inhibitor that inhibits the phosphorylation of STAT3 at site pTyr705. STAT3-IN-11 inhibits the phosphorylation of downstream genes (Survivin and Mcl-1) without affecting its upstream tyrosine kinases (Src and JAK2) levels and p-STAT1 expression. STAT3-IN-11 can induce cancer cell apoptosis, which is potential for the discovery of effective STAT3 inhibitors and antitumor agents against cancers[1].
- Target Antigen: Apoptosis; STAT
- Type: Reference compound
- Related Pathways: Apoptosis;JAK/STAT Signaling;Stem Cell/Wnt
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/stat3-in-11.html
- Solubility: DMSO : 100 mg/mL (ultrasonic)
- Smiles: O=C(NCCC(C1=O)=C(C)C(C2=C1C(O)=CC=C2)=O)C3=CC=CC=C3
- Molecular Weight: 335.35
- References & Citations: [1]Li N, et al. Design, synthesis and biological evaluation of novel plumbagin derivatives as potent antitumor agents with STAT3 inhibition. Bioorg Chem. 2020 Nov;104:104208.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported