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P2Y1 antagonist 2

CAT: 0804-HY-174126Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174126Size:1 Each
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Description
P2Y1 antagonist 2 (Compound 19) is a P2Y1 receptor antagonist (IC50: 0.49 μM) . P2Y1 antagonist 2 has significant antiplatelet aggregation activity and exerts its effects by inhibiting P2Y1 receptor. P2Y1 antagonist 2 can upregulate nuclear Nrf2 protein levels, exhibit neuroprotective effects, and resist oxidative stress damage. P2Y1 antagonist 2 can effectively reduce cerebral infarction area and improve neurobehavioral function, and can be used in the study of ischemic stroke[1].
UNSPSC
12352005
Target
P2Y Receptor
Related Pathways
GPCR/G Protein
Field of Research
Cardiovascular Disease
Smiles
NC1=NC(CON2C(C(O)=O)=C(N=C2C3=CC(C#N)=CC=C3)C(F)F)=CS1
Molecular Formula
C16H11F2N5O3S
Molecular Weight
391.35
References & Citations
[1]Zhang B, et al. Design, Synthesis, and Biological Evaluation of 4- (Difluoromethyl) -1H-imidazole-5-carboxylic Acids/4- (3-Cyanophenoxy) pyrimidine-5-carboxylic Acids as P2Y1 Receptor Antagonists for Ischemic Stroke Treatment. J Med Chem. 2025 Jun 12;68 (11) :10930-10952.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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