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SMU-037

CAT: 0013-GTR19273679-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273679-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SMU-037 is an orally bioavailable, selective ROS1 inhibitor with potent activity (IC50= 6.8 nM) and the ability to penetrate the blood-brain barrier. It exhibits approximately 25-fold selectivity for ALK and demonstrates remarkable sensitivity to the G2032R resistance mutation. SMU-037 inhibits the phosphorylation of ROS1 and its downstream MAPK-ERK signaling pathway, leading to cell cycle arrest and apoptosis. It effectively suppresses tumor growth in both subcutaneous and intracranial xenograft mouse models. SMU-037 is applicable for research related to non-small cell lung cancer (NSCLC) .
Storage Conditions
-20°C
Notes
For research use only.

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