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SMU-14a

CAT: 0013-GTR19257908-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19257908-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SMU-14a is a TLR3 inhibitor with an IC50 of 0.18 μM. It suppresses IL-6 secretion in mouse peritoneal macrophages and downregulates TNF-α in human peripheral blood mononuclear cells. The compound exerts anti-inflammatory effects by reducing the phosphorylation of p65, ERK, and TBK1 via the NF-κB, MAPK, and IRF3 signaling pathways, and by lowering serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) . SMU-14a is applicable in acute hepatitis research.
Field of Research
Cell Biology, Immunology & Inflammation, Signal Transduction
Molecular Formula
C24H20N4O
Storage Conditions
-20°C
Notes
For research use only.

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