SMU-C68

• Description:

  SMU-C68 is a highly selective small-molecule TLR1/2 heterodimer agonist (EC50=0.009 μM) . SMU-C68 activates NF-κB and MAPK pathways to promote pro-inflammatory cytokine release (e.g., TNF-α, IL-1β) . SMU-C68 is promising for research of cancers[1].

• UNSPSC:

  12352005

• Target:

  NF-κB; p38 MAPK; Toll-like Receptor (TLR)

• Related Pathways:

  Immunology/Inflammation; MAPK/ERK Pathway; NF-κB

• Field of Research:

  Cancer

• Smiles:

  CC(OC(C1=C(SC2=C1CCC2)NC(NC3=C4C=CC=NC4=CC=C3)=S)=O)C

• Molecular Formula:

  C21H21N3O2S2

• Molecular Weight:

  411.54

• References & Citations:

  [1]Zeng X, et al. Discovery of potent, selective human TLR1/2 agonists: N-quinoline-N'- (thiophen-2-yl) thiourea analogs for potential cancer immunotherapy. Eur J Med Chem. 2025 Nov 5;297:117968.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  TLR1; TLR2

• CAS Number:

  [2677039-75-5]