SMU-037

CAT: 0804-HY-178391Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-178391Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
SMU-037 is an orally active and selective ROS1 inhibitor that demonstrates potent activity (IC₅₀ = 6.8 nM) and possesses the ability to penetrate the blood-brain barrier. SMU-037 shows ~25-fold selectivity over ALK, and superior sensitivity against the G2032R mutation. SMU-037 attenuates phosphorylation of ROS1 and downstream MAPK-ERK signaling pathway, leading to cell cycle arrest and apoptosis. SMU-037 effectively suppresses tumor progression in both xenograft and intracranial mouse models. SMU-037 can be used for non-small cell lung cancer (NSCLC) research[1].
UNSPSC
12352005
Target
Apoptosis; ERK; p38 MAPK; ROS Kinase
Related Pathways
Apoptosis; MAPK/ERK Pathway; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
C[C@H](C1=CC(F)=CC=C1C2=CC=C(C=C2)F)OC3=C(N=CC(C4=CC=C(C=C4)N5CCNCC5)=C3)N.Cl
Molecular Formula
C29H29ClF2N4O
Molecular Weight
523.02
References & Citations
[1]Liu S, et al. Discovery of novel 3-Benzyloxyaminopyridines as orally available and intracranially active selective ROS1 inhibitors for combating the resistant ROS1G2032R mutation. Eur J Med Chem. 2025 Dec 15;300:118089.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-N12110-01SMU-CX1
HY-157793-01SMU-L11
HY-176192SMU-14a
HY-151626MRV03-037
HY-172888-01SPP-037
HY-171787PPA-037
HY-120387SMU-B
HY-175782SMU-R39
HY-175769SMU-V18
HY-175293SMU-C68

Alternative Products

CatalogName
MF-0116463-01SMU-L11
MBS5774553SMU-B
MF-0115286-01SMU-1k
MF-0119137-01SMU-C68
MF-0115147-01SMU-14a
MBS5784548VM4-037
MF-0115199-01SPP-037
MBS5816908MRV03-037
MBS130597-01AZ-037
MF-0148218-01PVP-037

Popular Products