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SMU-R39

CAT: 0013-GTR19272886-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19272886-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SMU-R39 is a TLR7 and TLR8 antagonist with IC50 values of 3.22 μM and 0.24 μM, respectively. It binds to recombinant mTLR7 protein (KD= 2.36 μM) and recombinant hTLR8 protein (KD= 105 nM) . SMU-R39 inhibits downstream NF-κB and MAPK signaling pathways, reducing the secretion and transcription of pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) in PBMCs and THP-1 cells. In an Imiquimod (IMQ) -induced psoriasis mouse model, SMU-R39 exhibits anti-inflammatory activity and may be used for researching autoimmune diseases such as psoriasis.
Storage Conditions
-20°C
Notes
For research use only.

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