Lysosomal P-gp targeted agent 1

CAT: 0013-GTR19258745-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19258745-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Lysosomal P-gp targeted agent 1 (Compound 14) is an antitumor drug that targets lysosomal P-glycoprotein (Pgp) . It is selectively transported to lysosomes via overexpressed Pgp, releasing nitric oxide that generates reactive oxygen species (ROS), causing lysosomal membrane permeabilization (LMP) and inducing apoptosis. This compound can overcome resistance mediated by P-glycoprotein, leading to cell cycle arrest while maintaining relatively low toxicity to normal cells. It exhibits antitumor activity by significantly inhibiting tumor growth.

CAS Number

3043797-88-9

Field of Research

Cell Biology, Immunology & Inflammation, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery, Protein Biochemistry, Signal Transduction

Smiles

O=N=1ON=C (OCCCOC2=CC=CC3=C2OC4=CC=CC (=C4) CCC5=CC=C (O) C (OC6=CC=C (C=C6) CC3) =C5) C1S (=O) (=O) C=7C=CC=CC7

Molecular Formula

C39H34N2O9S

Molecular Weight

706.76

Storage Conditions

-20°C

Notes

For research use only.

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Lysosomal P-gp targeted agent 1

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