Lysosomal P-gp targeted agent 1

CAT: 0931-T206140-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0931-T206140-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

3043797-88-9

Target

Apoptosis, Bcl-2 Family, Caspase, Reactive Oxygen Species, P-gp

Related Pathways

Membrane transporter/Ion channel, Immunology/Inflammation, Neuroscience, Metabolism, Apoptosis, Proteases/Proteasome, NF-κB

Bioactivity

Lysosomal P-gp targeted agent 1 (Compound 14) is an antitumor drug that targets lysosomal P-glycoprotein (Pgp) . It is selectively transported to lysosomes via overexpressed Pgp, releasing nitric oxide that generates reactive oxygen species (ROS), causing lysosomal membrane permeabilization (LMP) and inducing apoptosis. This compound can overcome resistance mediated by P-glycoprotein, leading to cell cycle arrest while maintaining relatively low toxicity to normal cells. It exhibits antitumor activity by significantly inhibiting tumor growth.

Smiles

O=N=1ON=C(OCCCOC2=CC=CC3=C2OC4=CC=CC(=C4)CCC5=CC=C(O)C(OC6=CC=C(C=C6)CC3)=C5)C1S(=O)(=O)C=7C=CC=CC7

Molecular Formula

C39H34N2O9S

Molecular Weight

706.76

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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Catalog	Name
HY-168953	Lysosomal P-gp targeted agent 1
TBI5492-25MG	Mito-lonidamine, Mitochondria-targeted antiglycolytic agent
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GTR19212547-01	P-CAB agent 2
HY-153219-01	P-CAB agent 2 (hydrochloride)
GTR19212967-01	P-CAB agent 2 hydrochloride
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MBS6108077-01	Tegosept (Drosophila anti-fungal agent) (p-Hydroxybenzoic acid methyl ester, Methyl 4-hydroxybenzoate, Nipagine)
HY-175522	P-gp-IN-31
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Lysosomal P-gp targeted agent 1

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