P-CAB agent 1

P-CAB agent 1

• CAS Number: 2374139-68-9
• UNSPSC Description: P-CAB agent 1 (compound B19) is a highly potent potassium-competitive acid blocker agent with an IC50 value of 60.50 nM for H+/K+-ATPase. P-CAB agent 1 has acceptable oral absorption in rats. P-CAB agent 1 can be used for researching acid-related disorders (ARDs)[1].
• Target Antigen: Potassium Channel
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel
• Applications: Neuroscience-Neuromodulation
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/p-cab-agent-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(N)C1=CC(C2=CC=CC(CN3N=C4CN(CC4=C3C5=CC=CC=C5F)C)=C2)=CC=C1
• Molecular Weight: 426.49
• References & Citations: [1]Wang X, et al. Design, synthesis and biological evaluation of novel 5-methyl-2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole derivatives as potent potassium-competitive acid blockers. Bioorg Med Chem. 2022 Jun 15;64:116765.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported