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KIM-161

CAT: 0013-GTR19257966-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19257966-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KIM-161 is a PIK3CA inhibitor. It demonstrates significant antiproliferative activity, with IC50 values of 1.428 and 1.562 μM against PI3KCA-mutant breast cancer cell lines MCF7 and T47D, respectively. KIM-161 induces apoptosis and cell cycle arrest by inhibiting the PI3K/AKT/mTOR signaling pathway, leading to ROS production. It is applicable for research on breast cancer and its PI3KCA-mutant subtypes.
CAS Number
2559686-28-9
Field of Research
Cell Biology, Immunology & Inflammation, Metabolism Research, Signal Transduction
Smiles
O=C\1N (C (C) =N/C1=C\C2=CC=C (OC) C=C2) C3=CC=C (CC (NCC4=CC=CC=C4) =O) C=C3
Molecular Formula
C27H25N3O3
Molecular Weight
439.51
Storage Conditions
-20°C
Notes
For research use only.

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