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WT-161

CAT: 0013-GTR19164309-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19164309-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A potent, selective, and bioavailable HDAC6 inhibitor with IC50 0.4 nM; displays >20-fold selectivity over HDAC1/2/3/8; selectively inhibits HDAC6 and dramatically increases levels of acetylated α-tubulin with little effect on global lysine acetylation in cells; reversibly and rapidly induces the accumulation of Ac-α-tubulin in MM cell lines, displays synergism with both BTZ and CFZ, caspase activation and apoptosis; demonstrates a significant antitumor effect in human MM cell xenograft mouse model combined with BTZ.
CAS Number
1206731-57-8
Product Name Alternative
WT 161 | WT161
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 100 mg/mL 218.08 mM
Smiles
O=C (NO) CCCCCCC (N/N=C/C1=CC=C (N (C2=CC=CC=C2) C3=CC=CC=C3) C=C1) =O
Molecular Formula
C27H30N4O3
Molecular Weight
458.55
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Octanoic acid, 8- (hydroxyamino) -8-oxo-, 2-[[4- (diphenylamino) phenyl]methylene]hydrazide

Chemical Information

8-(2-(4-(Diphenylamino)benzylidene)hydrazinyl)-N-hydroxy-8-oxooctanamide

LSM-6269 is a tertiary amine.

CAS Number1206731-57-8
PubChem CID44601455
IUPAC NameN'-hydroxy-N-[(E)-[4-(N-phenylanilino)phenyl]methylideneamino]octanediamide
Molecular FormulaC27H30N4O3
Molecular Weight458.6
XLogP4.9
Topological Polar Surface Area94
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count12
Heavy Atom Count34
Formal Charge0
Complexity603
SMILES
C1=CC=C(C=C1)N(C2=CC=CC=C2)C3=CC=C(C=C3)/C=N/NC(=O)CCCCCCC(=O)NO
InChI
InChI=1S/C27H30N4O3/c32-26(15-9-1-2-10-16-27(33)30-34)29-28-21-22-17-19-25(20-18-22)31(23-11-5-3-6-12-23)24-13-7-4-8-14-24/h3-8,11-14,17-21,34H,1-2,9-10,15-16H2,(H,29,32)(H,30,33)/b28-21+
InChIKey
KXWWYFKVBFUVIZ-SGWCAAJKSA-N
Chemical Structure
2D Structure
2D structure of 8-(2-(4-(Diphenylamino)benzylidene)hydrazinyl)-N-hydroxy-8-oxooctanamide
CAS: 1206731-57-8
CID: 44601455
Formula: C27H30N4O3
MW: 458.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight458.6
XLogP34.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count12
Exact Mass458.23179083
Monoisotopic Mass458.23179083
Topological Polar Surface Area94 Ų
Heavy Atom Count34
Formal Charge0
Complexity603
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
GYB73157-01WT-161
A20432-5WT-161 5mg
A20432-1WT-161 1mg
HY-100871RWT-161 (Standard)
A20432-50WT-161 50mg
A20432-10WT-161 10mg
A20432-2WT-161 2mg
A20432-100WT-161 100mg
A20432-25WT-161 25mg
A20432-10mM-DWT-161 10mM * 1mL in DMSO

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