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PROTAC SMARCA2 degrader-22

CAT: 0013-GTR19239698-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19239698-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTAC SMARCA2 degrader-22 (Compound 5) is a potent, cell-permeable small molecule that induces targeted degradation of the SMARCA2 (BRM) protein, demonstrating >90% degradation at 100 nM. It effectively suppresses the growth of A549 lung cancer cells in vitro with an EC50 below 250 nM, supporting its use in oncology and targeted protein degradation research.
CAS Number
2760246-90-8
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Smiles
C ([C@@H] (NC (CN1CCN (CC1) C2=CC=C (C=N2) C=3C=C (N=NC3) C4=C (O) C=CC=C4) =O) [C@] (C) (C) C) (=O) N5[C@H] (C (N[C@@H] (C) C6=CC=C (C=C6) C=7SC=NC7C) =O) C[C@@H] (O) C5
Molecular Formula
C44H51N9O5S
Molecular Weight
818
Storage Conditions
-20°C
Notes
For research use only.

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