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PROTAC SMARCA2 degrader-29

CAT: 0013-GTR19240780-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19240780-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTAC SMARCA2 degrader-29 (Example 87) is a potent and selective degrader of the BRM (SMARCA2) protein, exhibiting a DC50 in the 10-100 nM range while sparing the closely related BRG1 (SMARCA4) at concentrations above 1 μM. This molecule serves as a valuable chemical probe for investigating BRM-dependent functions in cancer biology and epigenetics research, both in vitro and in vivo.
CAS Number
2865193-25-3
Field of Research
Epigenetics & Chromatin, Neuroscience, Pharmacology & Drug Discovery
Smiles
OC1=C (C=2C=C3C (C=C (S3) C4CCN (CC4) C5CCN (CC5) C=6C=C ([C@H] (C (=O) N7[C@H] (C (N[C@@H] (C) C8=CC=C (C=C8) C9=C (C) N=CS9) =O) C[C@@H] (O) C7) C (C) C) ON6) =NN2) C=CC=C1
Molecular Formula
C47H54N8O5S2
Molecular Weight
875.11
Storage Conditions
-20°C
Notes
For research use only.

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