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PROTAC SMARCA2/4-degrader-22

CAT: 0013-GTR19238789-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19238789-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SMARCA2 degrader-14 (I-408) is a potent, dual SMARCA2/SMARCA4-targeting PROTAC. It induces profound degradation (Dmax >90%, DC50 <100 nM in A549 cells) of these chromatin remodelers, serving as a critical chemical probe for oncology research in vitro to study SWI/SNF complex function and synthetic lethality.
CAS Number
2568277-48-3
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Smiles
NC1=C (N2CC3N (C (C2) CC3) C=4N=CC (=CN4) [C@@H]5CC[C@@H] (C (N[C@H] (C (=O) N6[C@H] (C (NCC7=CC=C (C=C7) C8=C (C) N=CS8) =O) C[C@@H] (OC (C) =O) C6) C (C) (C) C) =O) CC5) C=C (N=N1) C9=C (O) C=CC=C9
Molecular Formula
C51H61N11O6S
Molecular Weight
956.17
Storage Conditions
-20°C
Notes
For research use only.

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