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PROTAC SMARCA2 degrader-32

CAT: 0013-GTR19241411-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19241411-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTAC SMARCA2 degrader-32 (Compound 27) potently degrades SMARCA2 with a DC50 of 1.3 nM and demonstrates anti-proliferative activity in NCI-H838 lung cancer cells (GI50 = 34 nM) . This molecule serves as a valuable chemical probe for studying SMARCA2 biology and targeted protein degradation in oncology research, both in vitro and in vivo.
CAS Number
3033586-50-1
Field of Research
Neuroscience, Pharmacology & Drug Discovery
Smiles
CC1 (C) C=2N (C=3C1=CC=C (C3) C4CCN (C[C@@H]5CC[C@H] (CC5) C6=CN ([C@H] (C (=O) N7[C@H] (C (N[C@@H] (C) C8=CC=C (C=C8) C9=C (C) N=CS9) =O) C[C@@H] (O) C7) C (C) (C) C) N=N6) CC4) C=%10C (C (=O) N2) =C (Cl) C=CC%10
Molecular Formula
C54H64ClN9O4S
Molecular Weight
970.66
Storage Conditions
-20°C
Notes
For research use only.

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