Products for Research Use Only

SNIPER (ABL) -013

CAT: 0013-GTR19224981-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19224981-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SNIPER (ABL) -013 is a heterobifunctional degrader that conjugates the ABL inhibitor GNF5 to the IAP ligand Bestatin. It induces proteasomal degradation of BCR-ABL with a DC50 of 20 μM, providing a valuable chemical tool for targeted protein degradation research in chronic myeloid leukemia models, both in vitro and in vivo.
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction
Smiles
O=C (NCCOCCOCCOCCNC ([C@H] (CC (C) C) NC ([C@@H] (O) [C@@H] (CC1=CC=CC=C1) N) =O) =O) C2=CC=CC (C3=NC=NC (NC4=CC=C (OC (F) (F) F) C=C4) =C3) =C2
Molecular Formula
C42H52F3N7O8
Molecular Weight
839.9
Storage Conditions
-20°C
Notes
For research use only.