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SNIPER (ABL) -020

CAT: 0013-GTR19224977-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19224977-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SNIPER (ABL) -020 is a conjugate of the ABL inhibitor Dasatinib and the IAP ligand Bestatin, linked to effectively degrade BCR-ABL. This proteolysis-targeting chimera (PROTAC) has demonstrated utility in both in vitro and in vivo research models for studying chronic myeloid leukemia (CML) and drug resistance mechanisms.
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction
Smiles
CC1=C (NC (C2=CN=C (NC3=CC (N4CCN (C (COCCOCCOCCNC ([C@H] (CC (C) C) NC ([C@@H] (O) [C@@H] (CC5=CC=CC=C5) N) =O) =O) =O) CC4) =NC (C) =N3) S2) =O) C (Cl) =CC=C1
Molecular Formula
C44H59ClN10O8S
Molecular Weight
923.52
Storage Conditions
-20°C
Notes
For research use only.

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