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SNIPER (ABL) -039

CAT: 0013-GTR19224974-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19224974-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SNIPER (ABL) -039 is a heterobifunctional degrader that conjugates Dasatinib to an IAP ligand, inducing BCR-ABL protein degradation with a DC50 of 10 nM. It demonstrates potent activity against ABL and IAP family proteins, making it a valuable chemical probe for targeted protein degradation research in oncology, applicable in both cellular and in vivo studies.
CAS Number
2222354-29-0
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction
Smiles
C ([C@@H] (NC ([C@@H] (NC) C) =O) C1CCCCC1) (=O) N2[C@@] (CCC2) (C3=NC (C (=O) C4=CC (OCCOCCOCCOCC (=O) N5CCN (CC5) C=6C=C (NC=7SC (C (NC8=C (C) C=CC=C8Cl) =O) =CN7) N=C (C) N6) =CC=C4) =CS3) [H]
Molecular Formula
C54H68ClN11O9S2
Molecular Weight
1114.77
Storage Conditions
-20°C
Notes
For research use only.

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