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SNIPER (ABL) -024

CAT: 0013-GTR19224976-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19224976-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SNIPER (ABL) -024 is a heterobifunctional degrader that conjugates the ABL inhibitor GNF5 to an IAP ligand, inducing the degradation of BCR-ABL with a DC50 of 5 μM. This PROTAC-like molecule serves as a valuable chemical tool for targeted protein degradation research in chronic myeloid leukemia models, both in cellular and biochemical studies.
CAS Number
2222355-77-1
Field of Research
Cardiovascular Research, Pharmacology & Drug Discovery, Signal Transduction
Smiles
C ([C@@H] (NC ([C@@H] (NC) C) =O) C1CCCCC1) (=O) N2[C@@] (CCC2) (C3=NC (C (=O) C4=CC (OCCOCCOCCOCCNC (=O) C5=CC (=CC=C5) C=6C=C (NC7=CC=C (OC (F) (F) F) C=C7) N=CN6) =CC=C4) =CS3) [H]
Molecular Formula
C52H61F3N8O9S
Molecular Weight
1031.15
Storage Conditions
-20°C
Notes
For research use only.

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