NS-1619

• Description :

  NS-1619 is an opener of large conductance Ca2+-activated K+ (BK) channel. NS-1619 is a highly effective relaxant with an EC50 of about 10-30 μM in several smooth muscles of blood vessels and other tissues[1]. NS1619 inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells[2].

• CAS Number :

  [153587-01-0]

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Apoptosis; Potassium Channel

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Membrane Transporter/Ion Channel

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Cancer; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/NS-1619.html

• Concentration :

  10mM

• Purity :

  99.32

• Solubility :

  DMSO : ≥ 31 mg/mL

• Smiles :

  O=C1NC2=CC(C(F)(F)F)=CC=C2N1C3=CC(C(F)(F)F)=CC=C3O

• Molecular Formula :

  C15H8F6N2O2

• Molecular Weight :

  362.23

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  2+2++

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported