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ABCB1-IN-2

CAT: 0931-T200374-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T200374-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
P-gp
Related Pathways
Membrane transporter/Ion channel, Neuroscience
Bioactivity
ABCB1-IN-2 (compound 16q) is a functional inhibitor that directly binds and stabilizes the ABCB1 protein structure without altering its expression and subcellular localization. This compound enhances the sensitivity of MCF-7/ADR cells to paclitaxel (PTX) by increasing PTX accumulation and inhibiting the ABCB1-mediated accumulation and excretion of luciferin Rh123. As a potent ABCB1-mediated multidrug resistance (MDR) reversal agent, ABCB1-IN-2 effectively reverses MDR.
Molecular Formula
C29H29N3O6S
Molecular Weight
547.62
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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