ABCB1-IN-2

• Target:

  P-gp

• Related Pathways:

  Membrane transporter/Ion channel|||Neuroscience

• Bioactivity:

  ABCB1-IN-2 (compound 16q) is a functional inhibitor that directly binds and stabilizes the ABCB1 protein structure without altering its expression and subcellular localization. This compound enhances the sensitivity of MCF-7/ADR cells to paclitaxel (PTX) by increasing PTX accumulation and inhibiting the ABCB1-mediated accumulation and excretion of luciferin Rh123. As a potent ABCB1-mediated multidrug resistance (MDR) reversal agent, ABCB1-IN-2 effectively reverses MDR.

• Molecular Formula:

  C29H29N3O6S

• Molecular Weight:

  547.62

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C